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Open Access
Peer-reviewed
Research Article
Quantifying critical states of complex diseases using single-sample dynamic network biomarkers
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Xiaoping Liu ,
Contributed equally to this work with: Xiaoping Liu, Xiao Chang
Roles Data curation, Formal analysis, Writing – original draft
¶‡ These authors shared first authorship.
Affiliations Institute of Industrial Science, the University of Tokyo, Tokyo, Japan, College of Statistics and Applied Mathematics, Anhui University of Finance and Economics, Bengbu, Anhui Province, China, Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, School of Mathematics and Statistics, Shandong University at Weihai, Weihai, China
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Xiao Chang ,
Contributed equally to this work with: Xiaoping Liu, Xiao Chang
Roles Data curation, Formal analysis, Writing – original draft
¶‡ These authors shared first authorship.
Affiliations Institute of Industrial Science, the University of Tokyo, Tokyo, Japan, College of Statistics and Applied Mathematics, Anhui University of Finance and Economics, Bengbu, Anhui Province, China
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Rui Liu,
Roles Supervision
Affiliation School of Mathematics, South China University of Technology, Guangzhou, China
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Xiangtian Yu,
Roles Supervision
Affiliation Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China
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Luonan Chen ,
Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing
* E-mail: lnchen@sibs.ac.cn (LC); aihara@sat.t.u-tokyo.ac.jp (KA)
Affiliations Institute of Industrial Science, the University of Tokyo, Tokyo, Japan, Key Laboratory of Systems Biology, CAS Center for Excellence in Molecular Cell Science, Innovation Center for Cell Signaling Network, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China, School of Life Science and Technology, ShanghaiTech University, Shanghai, China
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Kazuyuki Aihara
Roles Conceptualization, Funding acquisition, Supervision, Writing – review & editing
* E-mail: lnchen@sibs.ac.cn (LC); aihara@sat.t.u-tokyo.ac.jp (KA)
Affiliation Institute of Industrial Science, the University of Tokyo, Tokyo, Japan
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Quantifying critical states of complex diseases using single-sample dynamic network biomarkers
- Xiaoping Liu,
- Xiao Chang,
- Rui Liu,
- Xiangtian Yu,
- Luonan Chen,
- Kazuyuki Aihara
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- Published: July 5, 2017
- https://doi.org/10.1371/journal.pcbi.1005633