// what we showed them
// [node]
// -> = edge
// {nodes together}
primary [P]
detachment [A]
invasion [I]
breach ecm [R]
intravasation [V]
[B] = {I, R, V}
motility [O]
migration [T]
[C] = {O, T}
extravasation [D]
colonization [L]
proliferation [X]
angiogenesis [N]
[E] = {L, X, N}
micrometastasis [F]
macrometastasis [G]
// other steps/nodes suggested by experts
// ... = they said "and then the rest", so agreed with the diagram we showed them but did not explicitly mentioned the steps
// node' = different wording/description for that node
// node? = uncertain
vessel infiltration [J]
interactions with stroma [K]
events at primary [H]
something happens to cell [M]
EMT starts [Ui]
EMT [U]
lymph-&angio-genesis starts [Ni]
lymph-&angio-genesis [N]
ECM remodeling [ER]
progressive growth [PG]
[PG] = [E']
[Ei...n] = {E1, E2, E3, E4… En}
go somewhere [GS]
survival in circulation [SC]
energy pertubations [EP]
metastatic niche [MN]
trigger [TR]
oligometstasis [Q]
wide metastasis [WM]
metastatic seeding [Z]
floating around [FA]
adhesion [S]
MET [W]
in bloodstream [BL]
[BL] = [FA'] =[SC']
[H] = {P, M}
// what we showed them
P -> A -> B -> C -> D -> E -> F -> G
// 28
P -> {A, B, C} -> D -> {E1, E2, E3, E4… En} -> ...
// 27
P -> A -> B -> C -> D -> E -> F -> N -> G
// 26
P -> U? -> {A, U?, N?} -> {B, U?, N?} -> {C, N?} -> {D?, N?} -> {E, N?} -> {F, N?} -> {G, N?}
// 25
P -> A -> ? -> E -> ...
// 24
... -> N -> B -> ...
// 23
P -> M? -> A -> {I, R?, V} -> {O, T?} -> D? -> E -> ...
P -> M? -> A -> ? -> E -> ...
// in colorectal
M? = U
// 22
P -> A -> B -> SC -> D -> E -> ...
// 21
P -> A -> T -> B -> T? -> D -> ...
// 20
P -> A -> C -> I -> V? -> D? -> E -> F -> G
// 19
// in ovarian cancer: no intravasation/extravasation
P -> A -> B -> C -> D? -> C? -> E -> F -> G
// 18
... -> {A, B, C} -> D -> E -> ...
// 17
P -> A? -> B -> {C, SC} -> MN -> E -> F -> G
... D -> TR -> E -> ...
// 16
... -> {A, ER?} -> C -> V -> D -> ..
... -> A -> C -> B -> ...
{P, K} -> {A, ER} -> C -> B -> {SC, EP} -> D -> E -> {F, K} -> {G, K} -> {Q, K} -> {X, K}
// 15
P -> GS -> PG -> ...
// 14
P -> Z -> L -> ...
// in leukemia
BL -> L -> ...
// 13
P -> A -> FA -> T -> L -> F -> G
// in ovarian cancer, extravasation, proliferation and angiogenesis are not as important
// 12
H -> U -> ? -> W -> L -> ...
// 11
P -> {A, C} -> B -> {L, X, N?} -> F -> N? -> G
{A, B, C} = [U]
// 10
P -> C -> {A, B} -> D -> MN -> E -> ...
// 09
P -> A -> S -> E -> ...
// 08
... -> C -> B -> ...
P -> A -> C -> B -> ...
... -> C -> A -> B -> ...
// 07
// no order given, just the existence on some steps
A
I
O
...
// 6
{P, K} -> {A, B, C} -> ...
// 5
P -> N -> A -> ...
// 4
P -> A -> C -> B -> SC -> D -> ...
// 3 (no comments)
// 2
P -> ? -> PG -> F -> ...
// 1
P -> A -> I -> E -> ...