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Xuejin Li, E. Du, Ming Dao, Subra Suresh, George Em Karniadakis
Patient-specific modeling of individual sickle cell behavior under transient hypoxia
www.ploscompbiol.org
www.ploscompbiol.org
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(irreversible)Tj
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(sickle)Tj
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(cells)Tj
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(\(ISCs\),)Tj
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(respectively,)Tj
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(MCHC)Tj
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(values)Tj
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(considerably)Tj
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f*
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h
f*
0 g
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BT
/F2 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Table)Tj
2.7992 0 Td
(1.)Tj
1.2614 0 Td
(Selected)Tj
4.2733 0 Td
(hemato)Tj
3.5079 0 Td
(logic)Tj
2.5299 0 Td
(paramete)Tj
4.3725 0 Td
(rs)Tj
1.148 0 Td
(from)Tj
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(four)Tj
2.1402 0 Td
(SCD)Tj
2.3031 0 Td
(patients.)Tj
0 Tc
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(Off-HU)Tj
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(On-HU)Tj
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(S-P-I)Tj
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(S-P-II)Tj
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(S-P-III)Tj
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(S-P-IV)Tj
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(Hct,)Tj
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(18.6)Tj
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(21.9)Tj
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(29.2)Tj
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(MCV,)Tj
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(fL)Tj
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(83.3)Tj
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(99.0)Tj
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(MCHC,)Tj
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(g/dL)Tj
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(36.6)Tj
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(35.6)Tj
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(34.2)Tj
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-41.4711 -1.5591 Td
(HbS,)Tj
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(90.1)Tj
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(72.4)Tj
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(86.0)Tj
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(HbF,)Tj
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12.2883 0 Td
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(6.0)Tj
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(24.1)Tj
9.1276 0 Td
(10.0)Tj
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-41.4711 -1.559 Td
(HbA,)Tj
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(%)Tj
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12.4654 0 Td
(0.0)Tj
8.6599 0 Td
(0.0)Tj
8.9363 0 Td
(0.0)Tj
9.1347 0 Td
(0.0)Tj
/F2 1 Tf
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(HbA)Tj
ET
Q
q
1 j
1 J
0 w
5.9998 0 0 5.3325 216.3401 590.57 cm
BT
/F2 1 Tf
1 TL
0 0 Td
(2)Tj
ET
Q
q
1 j
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