A schematic representation of the relationship of the non-reverted and various conditions of the reverted HMT3522 breast cells.
The nonmalignant S1 cell is the root of the tree. It is also the parent of the malignant T4-2 cell since T4-2 cells were derived from S1. The T4-2 cells can be reverted to phenotypically normal-looking structures by treatment with various agents, such as: i) either EGFR or β1-integrin inhibitor, ii) either PI3K or MAPKK inhibitor, or iii) MMP inhibitors, they are thus represented as the parent of the various conditions of the reverted T4-2 cells. Microarray profiles were generated from each cell state represented in the tree, and gene networks specific to each state were reverse engineered using Treegl.
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