Clonal dominance and transplantation dynamics in hematopoietic stem cell compartments
Fig 6
Time taken until a clone initiated from a single cell represents 4% [39, 40] of the human HSC pool, as a function of the total number of niches in the system.
Colours represent the selective advantage of the invading clone. Lines are given by the solution of Eq (6), and shaded regions represent the calculated standard deviation (details in the S1 Supporting Information). Remaining parameters are β = 1/40 week−1 [62], ℓ = 60 minutes, s* = 0.01N, and n* = 0.99N. Here ℓ, s*, and n* are extrapolated from the murine data, where ℓhuman ≈ 10ℓmouse, which follows the same scaling as the HSC division rate, β. Further parameter combinations are shown in S1 and S2 Figs. References refer only to the source of parameters; no part of this figure has been reproduced from previous works.