Estimating the probabilities of rare arrhythmic events in multiscale computational models of cardiac cells and tissue
(a) DADs resulting from initializing SR Ca2+ load to five different values as shown in (b). (c) Volume renderings of Ca2+ in the simulations at three time points illustrating the greater spontaneous Ca2+ wave activity at higher SR Ca2+ loads. The number of Ca2+ wave nucleation sites (Nnuc) is tabulated for each simulation. All simulations initialized with [Na+]i = 10 mM.