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Estimating the probabilities of rare arrhythmic events in multiscale computational models of cardiac cells and tissue

Fig 2

Ventricular myocyte model properties.

(a) Normalized peak LCC (triangles) and RyR (circles) flux when the membrane was stepped to test potentials between -20 and 40 mV. (b) Excitation-contraction coupling gain, defined as the ratio of the normalized peak RyR to LCC Ca2+ flux at each test potential. (c) Representative action potentials and (d) [Ca2+]i transients under control conditions (solid black), with 50% IK1 inhibition (dashed black), with β-adrenergic stimulation (solid red) conditions, and with β-adrenergic stimulation and 50% IK1 inhibition (dashed red). (e) Cell-wide SR Ca2+ leak rate via RyRs at varying SR Ca2+ loads in the baseline model. The dotted line indicates the lowest SR Ca2+ load tested that exhibited spontaneous Ca2+ waves. (f) Example linescan plot showing a Ca2+ wave under β-adrenergic stimulation.

Fig 2