Modeling the adenosine system as a modulator of cognitive performance and sleep patterns during sleep restriction and recovery
Fig 2
Dynamics of the adenosine model under two simulated conditions: Acute sleep deprivation for 4 days (red line), and chronic sleep restriction with 4 h sleep per night for 8 days (black line).
Four model variables are shown as functions of time: (A) Unbound adenosine concentration, Au. (B) Total adenosine concentration, Atot. (C) Bound A1 receptor concentration, R1,b, which is used as a proxy for sleep homeostatic pressure in the model. (D) Total A1 receptor concentration, R1,tot. Red horizontal lines represent the level of each variable at the end of the 4 days of acute sleep deprivation.