Differential temperature sensitivity of synaptic and firing processes in a neural mass model of epileptic discharges explains heterogeneous response of experimental epilepsy to focal brain cooling
Wendling model captures several features of epileptic discharges before cooling such as average inter-discharge interval, magnitude and asymmetry of epileptic discharges. (a) Epileptic discharge activity before cooling (left) and simulated activity (right). Top plots are for rat 3 while bottom plots are for rat 4. (b) PSP from excitatory interneurons determine whether discharge activity tends to be symmetric (solid line) or asymmetric (broken lines) with respect to baseline.