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Differential temperature sensitivity of synaptic and firing processes in a neural mass model of epileptic discharges explains heterogeneous response of experimental epilepsy to focal brain cooling

Fig 6

Estimation of Wendling model from activity before cooling.

Wendling model captures several features of epileptic discharges before cooling such as average inter-discharge interval, magnitude and asymmetry of epileptic discharges. (a) Epileptic discharge activity before cooling (left) and simulated activity (right). Top plots are for rat 3 while bottom plots are for rat 4. (b) PSP from excitatory interneurons determine whether discharge activity tends to be symmetric (solid line) or asymmetric (broken lines) with respect to baseline.

Fig 6