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In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis

Fig 5

Modelling the electrophysiological properties of IKur carried by the mutants.

A Steady-state activation; B Steady-state inactivation; C I-V relationship of IKur elicited by voltage clamp step protocol for the (i) gain- and (ii) loss-of-function mutations, compared to the WT (black). In the plots points indicate the experimental data [2] and lines represent simulated results.

Fig 5

doi: https://doi.org/10.1371/journal.pcbi.1005587.g005