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In silico assessment of genetic variation in KCNA5 reveals multiple mechanisms of human atrial arrhythmogenesis

Fig 4

Model representation describing IKur and simulated voltage clamp.

A Steady-state activation and inactivation; B Time constants; C Current trace obtained from a simulated voltage clamp. Inserts: top right–voltage protocol; bottom right–experimental current traces; D I-V relationship. In the Fig the simulation data were shown using lines, and experimental data represented by points. Experimental data were taken from [2]; specially, for B the time constants were derived from current traces from [2] by fitting the activation phase of the current trace to a mono-exponential equation.

Fig 4

doi: https://doi.org/10.1371/journal.pcbi.1005587.g004