Mechanisms underlying different onset patterns of focal seizures
(A) Simulation of a low amplitude onset, similar to previously shown. The surround is monostable in the background state Psurround = −4. Snapshots of the sheet were taken at the time points indicated by the grey bars in the time series. (B) Simulation of a high amplitude onset, in this case using exactly the same microdomain location and dynamics as in (A). The surround is bistable with Psurround = −1.5. (C) Same simulation as (A), only without the resected tissue (marked by the grey box with the red cross). (D) Same simulation as in (B), only without the resected tissue (marked by the grey box with the red cross). The parameters used can be found in Table 1.