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Mechanisms underlying different onset patterns of focal seizures

Fig 1

Modelling low and high amplitude onset patterns.

(A) Low amplitude fast (LAF) onset pattern. Top: example clinical recording of a LAF pattern (onset indicated by red line), visualised from [17]. Middle: Simulated ECoG electrode recording of a LAF pattern. Seizure onset was initiated by activating patches of microseizure activity (marked by red line). Bottom: corresponding snapshots of the simulated activity on the cortical sheet. (B) High amplitude slow (HAS) onset pattern. Top: example clinical recording of a HAS pattern (onset indicated by red line), from the iEEG database www.ieeg.org, Study 020, seizure 3. Middle: Simulated ECoG electrode recording of a HAS pattern. Seizure onset was initiated by activating patches of microseizure activity (marked by red line). Bottom: corresponding snapshots of the simulated activity on the cortical sheet. The time scale of the clinical recordings is matched with those of the simulations. The red vertical bar in the simulation indicates T = 0 s. The parameters used can be found in Table 1.

Fig 1

doi: https://doi.org/10.1371/journal.pcbi.1005475.g001