A computational analysis of in vivo VEGFR activation by multiple co-expressed ligands
(A) Overview of key predictions. (B) Due to differences in NRP1- and ECM-binding, VEGF isoform-VEGFR2 complexes are trafficked differently, leading to distinct downstream signaling, cellular behavior, and vascular network architecture. (C) Summary of predicted ligand binding to VEGFR1 and VEGFR2. All ligands in the respective boxes can bind to VEGFR1 or VEGFR2. The size of the ligands represents the predicted contribution to receptor binding in vivo. The model suggests that, for each receptor, a subset of the ligands dominate.