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A computational analysis of in vivo VEGFR activation by multiple co-expressed ligands

Fig 8

Predicted signaling changes in the human body with expression of single VEGF isoforms mirror experimentally observed murine phenotypes.

(A) Levels of free VEGF, PlGF, and sR1 in tissue interstitial fluid, normalized to baseline, when all VEGF production is VEGF121, VEGF165, or VEGF189. (B) Endothelial cell surface ligation of VEGFR1 and phosphorylation of VEGFR2. Changes in pR2 and ligated VEGFR2 were very similar. (C) Ratio of total VEGFR2 phosphorylation on tyrosine Y1214 to phosphorylation of tyrosine Y1175. (D) Percent of ligated EC surface VEGFR1 and VEGFR2 bound to EBM-immobilized ligand.

Fig 8