A computational analysis of in vivo VEGFR activation by multiple co-expressed ligands
Panels show percent change from baseline. Thus, the smallest bars indicate little impact of the removed reactions on a given output, while large bars indicate large change when the reactions are removed. Cell Only: Immobilized ligand allowed to bind to EC receptors, but not sR1. Binding of ligand to immobilized sR1 is also not allowed. sR1 Only: Immobilized ligand allowed to bind to sR1, and ligand to immobilized sR1, but binding of immobilized ligand to EC receptors is not included. No MLR: No matrix-ligand-receptor or matrix-ligand-sR1 complexes are allowed to form. Top: Changes in fit ligand secretion and receptor production rates to match plasma ligand and sR1 targets and tissue EC surface receptor targets. Middle: Distribution of free, total, and matrix-bound VEGF and PlGF. Bottom: EC receptor activation.