Advertisement

< Back to Article

Patient-specific modeling of individual sickle cell behavior under transient hypoxia

Fig 5

Dependence of cell biodynamics on sickle cell shapes and mean cell volume in the Oxy and DeOxy states.

(a) Transit velocity of sickle cells with different shapes in the Oxy state obtained from experiment (black circles) and simulation (red squares). (b) Simulations of transit velocity of sickle cells in fractions I (SS1, black circles), II (SS2, red squares), and IV (SS4, blue diamonds) in the DeOxy state. (c) Simulations of transit velocity of individual sickle RBCs with different cell volume through 4-μm-wide (black circles) and 3-μm-wide (red squares) microgates.

Fig 5

doi: https://doi.org/10.1371/journal.pcbi.1005426.g005