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Patient-specific modeling of individual sickle cell behavior under transient hypoxia

Fig 3

Direct observation of single-cell capillary obstruction.

Four sequences of video images of hypoxia-affected sickle RBCs (indicated by white arrows) passing through microchannel constrictions before they are obstructed at the microgates. These sickle RBCs have translational (a) and flipping (b) motion, leading to parallel (a) or vertical (b) blockage, which may cause a transient (indicated by yellow arrows) or persistent (indicated by red arrows) blockage to blood flow. (c) Individual trajectories of hypoxia-affected sickle RBCs passing through microchannel constrictions. Each line shows an individual trajectory of a hypoxia-affected sickle RBC in microfluidic channel. The line segments, parallel to the horizontal axis, indicate transient or persistent (the topmost one, if any) occlusions caused by trapped sickle RBCs.

Fig 3