Using Chemical Reaction Kinetics to Predict Optimal Antibiotic Treatment Strategies
Fig 3
The benefit of high drug concentrations depends on the velocity with which the reaction reaches equilibrium.
These graphs show the dependence of the onset of antibiotic action as measured in time required for reaching the threshold fc on the drug concentration in fold-MIC. It is based on Eq (5). (A) Illustration of scenarios with different thresholds fc with a constant drug target half-life tbound of 36.5 min (kr = 10−3.5). Blue: fc = 10%, yellow: fc = 50%, green: fc = 90%. (B) Illustration of scenarios with different drug target half-lives tbound with a constant threshold fc = 50%. Blue: tbound = 11.5 min (kr = 10−3), yellow: tbound = 36.5 min (kr = 10−3.5), green: tbound = 1h 55min (kr = 10−4).