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Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data

Fig 6

Inference of chromosome 1 structure.

(A) Distance violations in a probabilistic calculation using a single copy of chromosome 1. The contact distance is shown as dashed red line. (B) Distances of contacting beads in copy 1 against distances in copy 2. (C) Experimental contacts classified into restraints formed in both copies (green) and contacts seen only in one of the two copies (dark blue: copy 1, light blue: copy 2). (D, E) Average structures of both copies of chromosome 1. (F) Average distance matrix with upper half showing the first copy of chromosome 1 and the lower half showing the second copy.

Fig 6

doi: https://doi.org/10.1371/journal.pcbi.1005292.g006