Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data
(A) Distance violations in a probabilistic calculation using a single copy of chromosome 1. The contact distance is shown as dashed red line. (B) Distances of contacting beads in copy 1 against distances in copy 2. (C) Experimental contacts classified into restraints formed in both copies (green) and contacts seen only in one of the two copies (dark blue: copy 1, light blue: copy 2). (D, E) Average structures of both copies of chromosome 1. (F) Average distance matrix with upper half showing the first copy of chromosome 1 and the lower half showing the second copy.