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Inferential Structure Determination of Chromosomes from Single-Cell Hi-C Data

Fig 3

Distance based modeling of the X chromosome.

(A) Histogram of sampled distance scale estimates γ. (B) Average distance matrix for the Gaussian error model with a flat plateau (upper diagonal) and for the lognormal model (lower diagonal). (C) Log evidence log Pr(D|I) for different data weighting parameters λ (the inverse temperature λ is varied from 10−4 to 1 in a replica exchange simulation to facilitate sampling of the posterior distribution).

Fig 3

doi: https://doi.org/10.1371/journal.pcbi.1005292.g003