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Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments

Fig 5

Three of four plausible Mechanisms falsified

Shown are measurements from identical Mouse Analog experiments for which one of the four different Mechanism configurations was implemented. Average distances from CV (in Sinusoid Segment grid spaces) of Death trigger events each time step was recorded. Hepatocyte Death (plotted in Fig 6) becomes detectable Death Delay hours following its Death trigger event. Values shown are 100-second moving averages to reduce the considerable variability within and between simulation steps. Only MGNZ-Mechanism achieved the Target Phenomenon. Circled trends 1 and 2 help falsify NZ- and MNZ-Mechanisms.

Fig 5

doi: https://doi.org/10.1371/journal.pcbi.1005253.g005