Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments
Location-dependent features (A) Only APAP metabolism configuration and the type of Metabolite formed are location-dependent in NZ-Mechanism. Target Phenomenon: pericentral necrosis begins first adjacent to CV and then moves (radially) outward in the PP direction. (B) GSH Depletion Threshold and probability of mitoD Mitigation event configurations are location-independent for NZ-Mechanism. However, one or both exhibit zonation (Methods) for GNZ-, MNZ-, and MGNZ-Mechanisms. (C) The relative locations of Hepatocytes are plotted in two different ways.