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Competing Mechanistic Hypotheses of Acetaminophen-Induced Hepatotoxicity Challenged by Virtual Experiments

Fig 1

Cooperation and collaboration between wet-lab and virtual experiments in improving mechanistic explanations of phenomena.

The workflow in each cycle has the same objective: challenge an explanatory hypothesis. Knowledge generated from right-side cycles is dependent on the combined strength of the four characteristics in Fig 3A. Knowledge gained from multiple right-side cycles can guide design of more efficient wet-lab experiments.

Fig 1

doi: https://doi.org/10.1371/journal.pcbi.1005253.g001