A Parsimonious Model of the Rabbit Action Potential Elucidates the Minimal Physiological Requirements for Alternans and Spiral Wave Breakup
Fig 3
Recovery of AP excitability virtual protocol.
A) Average Vm (●) of six experimental cells shown in inset, aligned to recovery time (RT: defined as the time at which Vm recovers to within 5 mV of the resting potential). B) Normalized peak INa (models: lines) or (experiments: ●) as a function of RT. Experimental values of RT at 50% (0.8 ± 0.8 ms) and at 82% (4.7 ± 0.8 ms) were taken from in Table 1 of [32]. The error bars in B) reflect the variability of AP shape of the six cells (see panel A). The novel action potential clamp virtual protocol is described in the text.