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Bayesian Top-Down Protein Sequence Alignment with Inferred Position-Specific Gap Penalties

Fig 4

Log-log plots of program runtimes as a function of the total input length.

Each data point corresponds to one MSA generated by the program indicated. Estimated time complexities based on trendline slopes were for: GISMO, tN0.96; Clustal-Ω, tN1.6; Kalign, tN1.6; MUSCLE, tN2.1 and Dialign tN2.2, where N is the total number of residues in the aligned sequences. A trendline is not shown for MAFFT because (with the–auto option) it uses one of several different algorithms depending on the input sequence set; this produces a discontinuity in the data points.

Fig 4