Single-Cell Co-expression Analysis Reveals Distinct Functional Modules, Co-regulation Mechanisms and Clinical Outcomes
(A) Examples of single-cell specific, bulk specific and shared co-expressed gene pairs. (B) The mapping of the top 1,000 positively correlated genes in single cells (or bulk tissues) to their correlation in bulk tissues (or single cells). Each line represent a gene pair. The cells (or tissues) were randomly partitioned into two sub-groups. (C) The mapping of the top 1,000 positively correlated genes in one sub-group to the other sub-group. (D) Clustering of glioblastomas based on gene expression profiles. Bulk samples from TCGA (TCGA-GBM), single-cell-derived average gene expression (Average-MGH) and 5 genuine bulk samples (Bulk-MGH) for single-cell sequencing.