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A Geometrically-Constrained Mathematical Model of Mammary Gland Ductal Elongation Reveals Novel Cellular Dynamics within the Terminal End Bud

Fig 1

Morphology characterization of the terminal end bud.

Glands from 5 and 6 week old mice were embedded, sectioned and stained for epithelial markers and measurements were taken of both cells and the TEB structure. A) Regional measurements of the TEB are represented in a scaled schematic (n values: Regions 1, 2, 5, and 6 = 15 TEBs, Region 3 = 23 TEBs, Region 4 = 8 TEBs, Region 7 layer diameter = 24 TEBs, lumen = 15 TEBs, length = 29 TEBs, Region 8 = 8 ducts). B) Mean cellular dimensions of the cap and myoepithelial cells, Regions 1–4 (whiskers denote range, n values: Region 1 length = 15 TEBs/ 45 cells, Region 1 width = 10 TEBs/ 126 cells. Region 2 length = 15 TEBs/ 56 cells, Region 2 width = 10 TEBs/ 115 cells. Region 3 length = 23 TEBs/ 273 cells, Region 3 width = 9 TEBs/ 36 cells. Region 4 length = 8 TEBs/ 197 cells, Region 4 width = 8 TEBs/ 197 cells). C) Mean cellular dimensions of body and luminal cells, Regions 5–8 (whiskers denote range, n values: Region 5 width/length = 5 TEBs/ 221 cells. Region 6 width/length = 5 TEBs/ 316 cells. Region 7 length/width = 4 TEBs/ 204 cells. Region 8 length/width = 6 ducts/ 301 cells). See also Table A in S1 Text and S2 Fig.

Fig 1

doi: https://doi.org/10.1371/journal.pcbi.1004839.g001