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Fast and Rigorous Computation of Gene and Pathway Scores from SNP-Based Summary Statistics

Fig 5

Power of pathway scoring methods across diverse traits and diseases.

Bar heights represent the number of pathways found to be significant after Bonferroni-correction. Within a given trait group, results are aggregated for all tested GWAS studies. 65 GWAS had at least one significant pathway in one of the tested methods. For each GWAS, the raw number of significant pathways was divided by the number of pathways found by the best performing method. This was done in order to avoid that a few studies with many emerging pathways dominate. We show results for the MOCS gene scores (SOCS gene score results are similar, see S6 Fig). (a) Results are aggregated over all trait groups. (b) Results for different trait groups.

Fig 5