Regulated CRISPR Modules Exploit a Dual Defense Strategy of Restriction and Abortive Infection in a Model of Prokaryote-Phage Coevolution
The inflow and outflow of different species are indicated. The figure shows the reactions influencing the total spacer and protospacer contents at any given time in the population. We use this reaction set to derive the rates of average spacer quota change over time. Squares in the top row correspond to the total protospacer and spacer content in the infected cell population; those in the bottom correspond to those in the free cell population. Note that while we model average spacer quotas this figure illustrate all the reactions that influence total spacer contents.