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Integrative Genomics-Based Discovery of Novel Regulators of the Innate Antiviral Response

Fig 3

Human and viral protein interaction networks connecting the known RLR pathway with the newly identified RIG-I factors DDX17 and SNW1.

Human proteins are represented by circles, viral proteins by rounded rectangles (purple nodes). Green nodes represent known components of the RLR pathway. Orange nodes (DDX17 and SNW1) are novel RIG-I pathway components discovered in our study, which are connected to the RLR network through interactions with the green nodes. Edges between human proteins represent physical interactions (both low- and high-throughput) obtained from BioGRID Release 3.3 [54]. Interactions between human and viral proteins were obtained from the PHISTO database (29 Sep. 2014) [28]. See S1 Fig for a more complete representation of the RLR pathway containing the curated set of 49 known RLR genes. LaCV, La Crosse virus; EBV, Epstein-Barr virus; SFSV, Sandfly fever Sicilian virus; PRRSV, Porcine reproductive and respiratory syndrome virus; HPV, Human papillomavirus.

Fig 3

doi: https://doi.org/10.1371/journal.pcbi.1004553.g003