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Comparative Analysis of Yeast Metabolic Network Models Highlights Progress, Opportunities for Metabolic Reconstruction

Fig 2

Comparing model genomic coverage and metabolite annotation.

Models clustered differently when compared using genomic coverage (A and B) or the subset of metabolites in each model that are annotated with reference to an external database such as the Chemical Entities of Biological Interest (ChEBI) database (C and D). Results are presented as heatmaps with dendrograms (A and C) and scatterplots of the normalized pairwise distance between models (B and D). Yellow bands in the heat map signify inclusion of a particular open reading frame in that model, and dendrogram clustering is based upon similarity.

Fig 2

doi: https://doi.org/10.1371/journal.pcbi.1004530.g002