A Pan-Cancer Catalogue of Cancer Driver Protein Interaction Interfaces
a) Structure showing an EGFR dimer in active conformation (based on). The residues involved in the EGFR-EGFR interaction for the left EGFR molecule are shown in red, the other EGFR protein is shown in blue, the two EGF ligands are shown in green and the lipid bilayer in brown. b) Histogram showing that most glioblastoma mutations (black bars) in EGFR are located in its dimerization interface (red bars). c) Protein expression in different glioblastoma populations. Patients with mutations in EGFR’s dimerization interface (shown in red) have higher levels of EGFR and phosphorylated EGFR proteins than those with other or no EGFR mutations (shown in green and blue respectively).