Connectivity Homology Enables Inter-Species Network Models of Synthetic Lethality
The heatmap represents the ratio of median parameters for the SL pairs of a given function versus all pairs of a given function. For example, the SL pairs of Signal Transduction have two-times greater values for inverse shortest path than for the non-SL pairs of Signal Transduction. Rows are clustered by node-pair parameter values (see Table 1). Parameter variance is plotted above the heat map. Single-node parameters (see Table 1) are consistently altered in SL regardless of function. However, node-pair parameters differ between functions. This distinction suggests that network substructure may dictate SL mechanisms associated with a specific function.