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Coupling Protein Side-Chain and Backbone Flexibility Improves the Re-design of Protein-Ligand Specificity

Fig 7

Sequence logos for predicted and naturally occurring binding site sequences.

Two representative examples showing the largest (left) and the smallest (right) improvement of coupled moves (middle row) over fixed backbone design (bottom row) with respect to profile similarity with natural sequences (top row). The height of the letter representing each amino acid corresponds to its frequency and the height of each column is inversely proportional to the sequence variation at that position.

Fig 7