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Molecular Dynamics Simulations of the Bacterial UraA H+-Uracil Symporter in Lipid Bilayers Reveal a Closed State and a Selective Interaction with Cardiolipin

Fig. 5

Mutations on the CL binding sites.

Occupancy plots for the location of cardiolipins (CL; green) around UraA. The occupancy was calculated as the average over the multiple coarse-grained simulations of the wild type and the mutated forms of UraA (Mut 1: UraAmut-1-CG, Mut 2: UraAmut-2-CG and Mut 3: UraAmut-3-CG; see Table 1).

Fig. 5

doi: https://doi.org/10.1371/journal.pcbi.1004123.g005