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Molecular Dynamics Simulations of the Bacterial UraA H+-Uracil Symporter in Lipid Bilayers Reveal a Closed State and a Selective Interaction with Cardiolipin

Fig. 1

Structure of UraA.

A. The core and the gate domains as suggested by Lu et al. [20] are shown in grey and cyan respectively. B. Snapshot from the end of one of the UraA-AT simulations. The same colors for UraA as in A are used. The POPE, POPG and CL are shown in blue, red and green respectively. The water solvent is shown in red. C. Sequence of UraA. The secondary structure is shown below the sequence. The same colors for the core and the gate domains as in A are used.

Fig. 1

doi: https://doi.org/10.1371/journal.pcbi.1004123.g001