The Roles of Post-translational Modifications in the Context of Protein Interaction Networks
Figure 2
Co-existence network of PTM-types in the proteome of Homo sapiens.
Nodes represent the protein sets associated with the different PTM-types. Edge width was set proportionally to the Jaccard index indicating the overlap between the different protein sets. Edge colors indicate significance with red highlighting PTM-pairs whose overlap was found significant based on Fisher’s exact test with FDR-adjusted p-value threshold set to 0.01, and green otherwise. Numbers in parentheses are the counts of significant “red” co-existence edges to other PTM-types.