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Analysis of Individual Protein Regions Provides Novel Insights on Cancer Pharmacogenomics

Figure 5

Enrichment map of the proteins associated with differential drug activity at both, whole-protein and individual region levels.

We performed a gene-set enrichment analysis by comparing Gene Ontology (GO) annotations of the 316 proteins associated with different drugs at both levels of resolution (whole-protein and individual PFRs) against the whole human genome. All the GO terms identified here showed an enrichment in the biomarker group, and most of them relate to pathways and functions associated with carcinogenesis, metastasis, and drug resistance, such as regulation of cell proliferation, kinase activity, cell migration, cell adhesion, MAPK cascade, or response to hypoxia. In the figure, GO terms are connected when they are related according to the gene ontology.

Figure 5

doi: https://doi.org/10.1371/journal.pcbi.1004024.g005