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Analysis of Individual Protein Regions Provides Novel Insights on Cancer Pharmacogenomics

Figure 2

Perturbations of different regions in the same protein can have different drug effects.

(a) Missense mutations in different PFRs of MSH6 lead to increased sensitivity towards three different drugs: AEW541, RAF5 and Lapatinib. The protein level analysis on the other hand reveals a potential association with Erlotinib (shown in blue). This highlights the complementarity between protein and PFR-centric approaches.

Figure 2

doi: https://doi.org/10.1371/journal.pcbi.1004024.g002