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Lipid Clustering Correlates with Membrane Curvature as Revealed by Molecular Simulations of Complex Lipid Bilayers

Figure 4

Protein-lipid interactions within a plasma membrane model.

Interactions within 6 Å between protein and lipids head groups. (A) The average number of interactions between the protein and lipids mapped into the sequence. (B) Number of interactions between the PO3 bead of PIP2 and amino acid residues within the proteins. (C) Number of interactions between the ROH bead of cholesterol and the residues within the proteins. (D) The average number of contacts between the protein and PIP2 and cholesterol has been mapped into the protein structure. Interactions that are present in more than 50% of the entire simulations have been shown as surfaces.

Figure 4