Regression Analysis of Combined Gene Expression Regulation in Acute Myeloid Leukemia
Figure 7
A. The network drawn by Cytoscape 3 [54] comprises 18 selected regulators (blue diamond) having nonzero putative interactions with leukemia-related genes (red circle) obtained from COSMIC or MSigDB. The blue and grey edges indicate miRNA-mRNA and TF-gene regulatory relationships, respectively. B. A subnetwork containing the selected regulators and their targets. The selected regulators form a 3-layer hierarchical structure with 3 master regulators hsa-miR-548p, C-Fos, PHF8 on the top layer, one intermediate regulator YY1 in the middle layer, and two downstream regulators CCNT2 and BCLAF1 arranged at the bottom layer.