Linear Motif-Mediated Interactions Have Contributed to the Evolution of Modularity in Complex Protein Interaction Networks
(a) DLI/DDI information improves the identification of biological modules. (b) Quality of modules identified using conventional PPI data vs. DLI/DDI data. Module quality reflects the similarity of biological annotations in protein pairs within modules. (c) A detail of the merge process for conventional PPI and DLI/DDI-identified modules. The two horizontal arrows represent the merge process for seven proteins associated with ‘Voltage-gated Na+/K+ channels’ and ‘Fcε signaling pathway’. Ordinal numbers of specific merge steps are shown.