Linear Motif-Mediated Interactions Have Contributed to the Evolution of Modularity in Complex Protein Interaction Networks
(a) Categorizing human PPIs as DDIs or DLIs. A part of the human PPI network is shown to visualize DDI/DLI-assigned network. (b) Quality assessment of linear motifs during classification process. (c) Comparison of DDIs and DLIs categorized using our method to reference sets. (d) Edge clustering coefficients of DDIs and DLIs in the human PPI network. Grey bars show the distribution of average edge clustering coefficients in 105 networks with randomly assigned DDIs and DLIs.