Depletion of the Chromatin Looping Proteins CTCF and Cohesin Causes Chromatin Compaction: Insight into Chromatin Folding by Polymer Modelling
When keeping the long-range looping probability (plong) constant while varying short-range looping probability (pshort), the number of long-range loops (nlong) increases when reducing pshort. This is because lowering pshort reduces the loop repulsion on the short scale and hence increases intermingling on the long scale, which in turn increases the frequency of long-range loop formation. Here, plong = 0.06 and pshort is varied from 0.02 to 0.16. The blue area marks the short-range looping regime (<50 monomers) while the rest describes the long-range looping.