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Depletion of the Chromatin Looping Proteins CTCF and Cohesin Causes Chromatin Compaction: Insight into Chromatin Folding by Polymer Modelling

Figure 5

Heat plots showing how polymer compaction varies in the pshort - plong parameter space.

Polymer compaction is represented as MSD plateau level as shown in Figure 4. (A) adapted DL polymer, (B) domain-adapted DL polymer. The arrows in (A) show that decreasing the short-range looping probability (red arrow) results in compaction, while reducing the long-range looping probability (green arrow) leads to de-compaction. In the heat plot red marks compaction, green decompaction.

Figure 5