Depletion of the Chromatin Looping Proteins CTCF and Cohesin Causes Chromatin Compaction: Insight into Chromatin Folding by Polymer Modelling
Polymer compaction is represented as MSD plateau level as shown in Figure 4. (A) adapted DL polymer, (B) domain-adapted DL polymer. The arrows in (A) show that decreasing the short-range looping probability (red arrow) results in compaction, while reducing the long-range looping probability (green arrow) leads to de-compaction. In the heat plot red marks compaction, green decompaction.