Depletion of the Chromatin Looping Proteins CTCF and Cohesin Causes Chromatin Compaction: Insight into Chromatin Folding by Polymer Modelling
(A) Varying the short-range looping probability at constant long-range looping probability (plong 0.03). (B) Varying long-range looping probability at constant short-range looping (pshort 0.03). The MSD plateau levels is a measure of overall polymer compaction. The simulations show that decreasing the long-range looping probability results in expansion of the polymer, while lowering short-range looping probability leads to compaction. To facilitate comparison between the two effects, the MSD was normalized by the plateau level of the MSD for plong = 0.03 and pshort = 0.03 (MSDref) because this parameter combination is present in both figures.