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The Structural Basis of ATP as an Allosteric Modulator

Figure 4

The interactions between UMP kinase and allosteric and substrate ATP molecules.

(A) The energy contributions to the binding of allosteric and substrate ATP molecules to the UMP kinase, and the binding modes between the allosteric and substrate ATP molecules and the UMP kinase. The green dashes represent hydrogen bonds. The hydrogen atoms are not displayed for clarity. (B) The volume and shape of the allosteric and substrate ATP-binding sites of the UMP kinase.

Figure 4

doi: https://doi.org/10.1371/journal.pcbi.1003831.g004