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The Structural Basis of ATP as an Allosteric Modulator

Figure 2

Comparison of evolutionary conservation of allosteric and substrate ATP-binding sites.

(A) Distributions of conservation scores for residues in the allosteric and substrate ATP-binding sites as well as in the surface of proteins. (B) Distributions of average conservation scores for residues in the substrate and allosteric ATP-binding sites and the surface per protein. The statistical significant (P-value) was calculated by the Mann-Whitney U test.

Figure 2

doi: https://doi.org/10.1371/journal.pcbi.1003831.g002