Clique of Functional Hubs Orchestrates Population Bursts in Developmentally Regulated Neural Networks
Figure 1
Single neuron stimulation (SNS) can stop population bursting activity in presence of type T1 plus T2 correlations.
A sketch of a SNS experiment for a network with type T1 plus T2 correlations is reported in (A) and (B): the neuron is stimulated with a DC step for a time interval
(as shown by the red line on the top panel). Average firing rate of neuron
(A) and network activity (B) as measured during the experiment. (C) and (D) refer to correlated and uncorrelated networks, respectively. Upper panels display the number of population bursts, PBs, delivered during SNS experiments versus the stimulated neuron, ordered accordingly to their average firing rates
under control conditions (bottom panels). Each neuron
was stimulated with a DC step (switching its excitability from
to
) for an interval
s. The critical neurons are signaled by red circles. The number of PBs, emitted in control conditions within an interval
s, are also displayed: red dashed lines indicate their averages, while the shaded gray areas correspond to three standard deviations. The data refer to
mV and
neurons.